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INTRAPANCREATIC M2 POLARIZATION OF MACROPHAGES TO TREAT TYPE 1 DIABETES
INTRAPANCREATIC M2 POLARIZATION OF MACROPHAGES TO TREAT TYPE 1 DIABETES
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机译:巨噬细胞的血管包瘤M2偏极治疗1型糖尿病
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摘要
Methods are disclosed for polarizing macrophages to become M2 macrophages. Methods also are disclosed for treating type 1 diabetes in a subject. These methods include administering to the subject a vector comprising a macrophage specific promoter operably linked to a nucleic acid molecule encoding TNF-alpha-induced protein 8-like 2 (TIPE2) protein. In some embodiments, the vector is administered locally to a pancreas of the subject. In further embodiments, compositions are disclosed including a) a vector comprising a macrophage specific promoter operably linked to a nucleic acid molecule encoding TNF-alpha-induced protein 8-like 2 (TIPE2) protein; b) a buffer; and c) a contrast dye for endoscopic retrograde cholangiopancreatography.
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