METHOD FOR MANUFACTURING ANTHRAX SPORE VACCINES USING SPORE SURFACE DISPLAY AND ANTHRAX SPORE VACCINES

摘要

The present invention relates to a method for producing an anthrax spore vaccine and to an anthrax spore vaccine, comprising: culturing a spore-forming microorganism to express the target protein in the spore-forming microorganism; displaying and displaying the expressed target protein on the surface of the spore; and obtaining, from the spore-forming microorganism, spores in which the target protein is surface-displayed and the target protein is surface-displayed, wherein the target protein is surface-displayed in a non-fused natural state, and the target protein is It relates to a method for producing an anthrax spore vaccine and anthrax spore vaccine, which is a recombinant anthrax protective antigen (rPA). In addition, the present invention may provide an anthrax vaccine pharmaceutical composition and anthrax immunization method using the anthrax spore vaccine.