METHOD FOR SELECTIVELY KILLING PROTEIN AGGREGATE-CONTAINING CELLS, KIT THEREFOR, THERAPEUTIC DRUG FOR PROTEIN MISFOLDING DISEASES AND DRUG PRODUCT FOR REMOVING PROTEIN AGGREGATES FROM BLOOD PRODUCT

摘要

Provided are: a method for selectively killing protein aggregate-containing cells; a kit therefor; a therapeutic drug for protein misfolding diseases; and a drug product for removing protein aggregates from a blood product. The method for selectively killing protein aggregate-containing cells according to one embodiment comprises treating cells with a molecular structure-modifying agent, the molecular structure-modifying agent containing a fluoroalcohol or a compound represented by general formula (1) as a compound detecting protein aggregates, and thus selectively killing protein aggregate-containing cells. [In general formula (1): a is 0 or 1; when a is 1, then R¹ is a hydrogen atom and R² is a hydroxyl group, or R¹ is a hydroxyl group and R² is a hydrogen atom; when a is 0, then R² is an oxygen atom forming a double bond together with a carbon atom; R³ is CH_lCl_mF_n; l, m and n are an integer of from 1 to 3, provided that l+m+n equals to 3; R⁴ is CH_sCl_tF_u; and s, t and u are an integer of from 1 to 3, provided that s+t+u equals 3.]