ANTITUMOR AGENT CONTAINING IMMUNOMODULATOR AND ANTITUMOR EFFECT ENHANCER

摘要

FIELD: pharmaceuticals.;SUBSTANCE: group of inventions relates to the field of pharmaceuticals and can be used for treatment of malignant tumors, in particular malignant tumors of the gastrointestinal tract, lungs or breast. A method of treating a tumor comprises administering effective doses of a DNA function inhibitor and an immunomodulator to a subject in need thereof, while the DNA function inhibitor is a drug combination containing trifluridine and tipiracil hydrochloride in a molar ratio of 1:0.5, and the immunomodulator is an anti-PD-1 antibody or anti-PD-L1 antibody and while the daily dose of trifluridine at date of administration is 35 to 80 mg/m²/day. The group of inventions also relates to a method for potentiating the antitumor effect of the specified immunomodulator, comprising administering an effective dose of the inhibitor of DNA function to a subject in need thereof. ;EFFECT: group of inventions provides increased antitumor effect of the immunomodulator. ;20 cl, 11 tbl, 4 ex, 17 dwg