Enhanced therapeutic effect of an antitumor agent on malignant glioma in rats by photomechanical wave-based transvascular drug delivery

摘要

Malignant glioma is one of the most deadly malignancies due to the blood-brain barrier (BBB), which limits the delivery of an antitumor drug to the tumor. In this study, we used a nanosecond pulsed laser-induced photomechanical wave (PMW) to enhance the delivery efficiency of an antitumor drug, temozolomide (TMZ) through the blood-brain barrier (BBB) in a F98 rat glioma model. Seven days after glioma cell injection into the brain, rats were divided into four groups: control without any treatment (group 1); PMW application alone (group 2); TMZ application alone (group 3); and combined application of PMW and TMZ (group 4). Seven days after these treatments, rats were sacrificed and tumor sizes were evaluated. The tumor size of group 4 was significantly smaller than that of group 1, while there was no significant difference in the tumor size between groupl and group 3. This shows that the therapeutic effect of TMZ can be enhanced by PMW application.