VACCINE STRAIN OF INFLUENZA B/60/COLORADO/2017/1 (VICTORIA LINE) FOR THE PRODUCTION OF LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN

摘要

FIELD: virology.;SUBSTANCE: proposed is influenza virus strain B / 60 / Colorado / 2017/1 (Victoria Line). It was obtained on the basis of the epidemic virus B / Colorado / 06/17 (Victoria line) and a cold-adapted attenuation donor B / USSR / 60/69, harmless to humans. The claimed strain is characterized by temperature sensitivity and cold adaptation, harmlessness to laboratory animals. The strain contains genes encoding the surface proteins of the influenza virus hemagglutinin (HA) and neuraminidase (NA), inherited from an antigenically relevant circulating epidemic strain, and the remaining six genes encoding internal and non-structural proteins (PB2, PB1, PA, NP, M, NS) from an attenuation donor harmless to humans. ;EFFECT: strain B / 60 / Colorado / 2017/1 (Victoria Line) can be used in medicine to prevent the incidence of influenza among adults and children as part of a live influenza intranasal vaccine.;1 cl, 4 tbl