Inhibitor compostion for TLR4-MD2 comprising fraction of ethanol extract of Hibiscus Syriacus

摘要

In the present invention, a fraction of the ethanol extract of Mugunghwa or a flavonoid compound isolated therefrom binds to TLR4-MD, inhibits the activity of TLR4-MD, inhibits the activation of TLR4-MD induced by LPS, and inhibits and prevents the inflammatory reaction. . Specifically, it inhibited the production of NO induced by LPS, effectively inhibited the expression of iNOS and COX-2 proteins and pro-inflammatory cytokines TNF-α, IL-6, and IL-12, and the survival rate of the sepsis zebrafish model and It was confirmed that it has an anti-inflammatory effect by reducing teratogenicity. Therefore, the fraction of the ethanol extract of Mugunghwa can be used for prevention, improvement or treatment of inflammatory diseases or/and for alleviating skin inflammation.