USE OF EXOSOME DERIVED FROM MESENCHYMA STEM CELLS CO-CULTURED WITH MELATONIN IN DIAGNOSIS AND TREATMENT OF CHRONIC KIDNEY DISEASE

摘要

The present invention relates to the use of normal human-derived mesenchymal stem cells co-cultured with melatonin or exosomes extracted from a culture medium thereof in the treatment of chronic kidney disease. More specifically, the present invention is a pharmaceutical composition for the treatment or prevention of chronic kidney disease, comprising, as an active ingredient, an exosome extracted from a normal human-derived mesenchymal stem cell co-cultured with melatonin or a culture medium thereof, It relates to a method of preparing a pharmaceutical composition for treatment or prevention, and a method of promoting proliferation or increasing survival rate of mesenchymal stem cells derived from chronic kidney disease patients.