Procedure for the preparation of derivatives of the theory (Machine-translation by Google Translate, not legally binding)

摘要

Process for the preparation of thebaine derivatives, of general formula ** (See formula) ** wherein Y represents an ethene group, -CH = CH-, or ethane, -CH2-CH2-; R represents a hydrogen atom, a methyl group, an ethyl group, a propyl group, the group CnH2n + 1Co- wherein n is an integer from 1 to 3 inclusive, benzoyl or nicotinoyl, R1 represents a hydrogen atom, a methyl group, an ethyl group, a propyl group, the group CnH2n + 1Co- wherein n is an integer from 1 to 3 inclusive, benzoyl or nicotoil; in the assumption that when R = H, R '= H and that when R = acyl, R' is the same acyl group; R 2 represents a hydrogen atom, an acetonyl group, a phenacyl group, an alkyl, alkenyl or alkynyl group, whose alkyl, alkenyl or alkynyl groups can contain up to 8 carbon atoms and can be substituted on carbon atoms numbered 1 to 5. , the carbon with the number 1 being adjacent to the nitrogen atom, by alicyclic groups, substituted aryl, alkoxy aryl, aryloxy, substituted aryloxy, heterocyclic or substituted amino; R3 represents an alkyl, alkenyl or alkynyl group with a content of up to three carbon atoms, an aryl group or a substituted aryl group; R4 represents a hydrogen atom; an alicyclic group containing 3 to 7 carbon atoms, an alkyl, alkenyl, or alkynyl group containing up to 8 carbon atoms whose alkyl, alkenyl or alkynyl groups may be substituted on the carbon atoms numbered 1 to 4, being adjacent the atom with the number 1 to the carbon atom having the double bond, by alicyclic, aryl, substituted aryl, alkoxy, aryloxy or substituted aryloxy groups; characterized in that it comprises the step of reacting with an oxidizing acid an alcohol having one of the following three general formulas: ** (See formula) ** in which R, R1, R2, R3, R4 and Y have the same meanings indicated above, assuming that when Y is ethene in the formula "C", R3 = R4 = methyl. (Machine-translation by Google Translate, not legally binding)