still for framstellning of 7 / d - alpha - amino - and alpha - (p - hydroxyphenyl) acetamido / - 3 - (1,2,3 - triazole 5 - yltimometyl) - 3-cephem-4-carboxylic acid - 1,2 - propylenglykolat - 1.0 - 1.6 mol per mol of 1,2 - propylene glycol.

摘要

The antibacterial agent 7-[D- alpha -amino- alpha -(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem -4-carboxylic acid, which is a zwitterion, is both purified and converted to a form highly suitable for use in aqueous suspensions by converting it to the crystalline 7-[D- alpha -amino- alpha -(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem -4-carboxylic acid 1,2-propylene glycolate, said propylene glycolate containing 1.0 - 1.6 moles of 1,2-propylene glycol per mole of cephalosporin zwitterion.