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FREMGANGSMAATE FOR FREMSTILLING AV TERAPEUTISK AKTIVE NAFTALENDERIVATER

机译:具有治疗活性的纳夫塔尔衍生物的制备方法

摘要

Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 and R.sup.2 are lower alkoxy or lower alkylthio;PPR.sup.3 is hydrogen, lower alkyl, lower alkoxy, optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, halo, cyano, or S(O). sub.n R wherein R is lower alkyl; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or optionally substituted heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and the pharmaceutically acceptable acid addition salts thereof; and n is 0, 1 or 2; andPPW is alkyl of one to seven carbon atoms.
机译:通过局部施用下式的萘可缓解哺乳动物的牛皮癣:其中:R.sup.1和R.sup.2是低级烷氧基或低级烷硫基; P

R.sup.3是氢,低级烷基,低级烷氧基,任选取代的苯基,任选取代的苯基低级烷基,任选取代的苯基低级烷氧基,氨基,低级烷基氨基,低级二烷基氨基,卤素,氰基或S(O)。 sub.n R其中R为低级烷基;任选取代的苯基;任选取代的苯基低级烷基;或三至九个环原子的任选取代的杂环芳基,其含有一个或两个选自氮,氧和硫的杂原子,及其药学上可接受的酸加成盐; n为0、1或2; P P W为碳原子数1〜7的烷基。

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