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derivatives of 1 - aryl - 2 - aminomethyl - cyclopropancarboxamiden (z), their production and their use for the treatment of stoerungen of the central nervous system.
derivatives of 1 - aryl - 2 - aminomethyl - cyclopropancarboxamiden (z), their production and their use for the treatment of stoerungen of the central nervous system.
The present invention concerns new derivatives of 1-aryl 2-aminomethyl cyclopropane carboxamides (Z) of general formula I: IMAGE (I) in which: R represents a hydrogen or halogen atom, a lower alkyl group, a lower alkoxy group, or a hydroxy. nitro or amino group; n represents the value 1 or 2; R1 and R2 represent a hydrogen atom, a lower alkyl group, an aryl or lower alkaryl group, possibly substituted, preferably in para position, by a halogen atom, preferably a chlorine atom; R1 and R2 may also form a heterocycle having 5 or 6 members with the adjacent nitrogen atom; R3 and R4 represent a hydrogen atom or a lower alkyl group; R3 and R4 may also form with the adjacent nitrogen atom a heterocycle having 5 or 6 members, possibly containing an additional heteroatom selected from among nitrogen and oxygen, as well as their salts with therapeutically acceptable inorganic or organic acids, and their pharmaceutical compositions and use in the treatment of central nervous system disturbances, e.g., depression.
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机译:本发明涉及通式I的1-芳基2-氨基甲基环丙烷甲酰胺(Z)的新衍生物:(I)其中:R代表氢或卤素原子,低级烷基,低级烷氧基,或羟基。硝基或氨基n表示值1或2; R1和R2代表氢原子,低级烷基,芳基或低级烷芳基,它们可能优选在对位被卤素原子,优选氯原子取代; R1和R2还可以与相邻的氮原子形成具有5或6个成员的杂环; R 3和R 4表示氢原子或低级烷基。 R3和R4还可以与相邻的氮原子形成具有5或6个成员的杂环,可能含有选自氮和氧的另外的杂原子,以及它们与治疗上可接受的无机或有机酸的盐,以及它们的药物组合物和用途用于治疗中枢神经系统疾病,例如抑郁症。
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