Procedure for the treatment of vitamin B12 fermentation Liquid containing corrinoids and others to prepare Concentrated Vitamin B12 and Vitamin B12 Crystalline

摘要

Process for the preparation of concentrated Vitamin B12.This is the liquid fermentation, which contains cells of Microorganisms is not Broken, with nonionic macroreticular adsorption Resin with Taman / or pores of 10c8 until 10c7 m, a diameter of grains at least 10C4 M and a specific surface area of at least 200 m2 / g, and after the So, after the disintegration of the cells made from known Way, setting the corrinoids.In a second stage of adsorption, adsorption macrorreticular rsina in a same or different, but also non Ionic, and eluted with an organic Solvent miscible with water, Aqueous eventually.