Monoclonal anti-leishmania antibodies, hybridomas secreting these antibodies, leishmania antigens recognized by these anticoprs, process for obtaining and applications of these monoclonal antibodies and of these antigens.

摘要

PCT No. PCT/FR85/00264 Sec. 371 Date Jul. 31, 1986 Sec. 102(e) Date Jul. 31, 1986 PCT Filed Sep. 26, 1985 PCT Pub. No. WO86/02098 PCT Pub. Date Apr. 10, 1986.The invention concerns hybridomes producing anti-Leishmania monoclonal antibodies which are characterized by their capacity to inhibit the infection of sarcomatous cells by the promastigote forms of one or more species of Leishmania, when the sarcomatous cells are placed in contact with the said promastigote forms pre-incubated with these monoclonal antibodies under conditions which, in the absence of the said monoclonal antibodies, would lead to an elevated parasitemia in the said cells. These monoclonal antibodies and the proteins of the parasites that they recognize may be used in the operations of leishmanioses detections.