The DNA sequence coding for a protein having substantially the same biological activity as human protein C, as well as procedure for the preparation of this protein

摘要

Genomic and cDNA sequences coding for a protein having substantially the same biological activity as human protein C and recombinant expression vectors comprising these sequences are disclosed. Methods are disclosed for producing a protein which has substantially the same biological activity as human protein C. The protein, which may be in the form of activated protein C, is produced by mammalian host cells transfected with a plasmid capable of integration in mammalian host cell DNA. The plasmid includes a promoter followed downstream by a DNA sequence which encodes a protein having substantially the same structure and/or activity as human protein C, the nucleotide sequence being followed downstream by a polyadenylation signal.