3*77DISUBSTITUTEDD2 OR 33CEPHEMM44CARBOXYLIC ACID COMPOUND OR ITS SALT* THEIR PREPARATION* AND PREVENTIVES AND REMEDIES FOR MICROBISM COMPRISING THEM AS ACTIVE CONSTITUENTS

摘要

New 3,7-disubstituted-2 or 3-cephem-4-carboxylic acid compounds of the formula: …CHEM… wherein… R1 is amino or a substituted amino group;… R2 is carboxy or a protected carboxy group;… the group of the formula: …CHEM… is di(lower)alkylamino (lower)alkylamino, a N-containing heterocyclic (lower)alkylamino group which may have suitable substituent(s), a heterocyclic group containing 2 to 4 nitrogen atoms which may have suitable substituent(s) or hydroxypiperidino; and X is -S- or 0;… -S- e.g. 7-[2-methoxyimino-2- (2-aminothiazol-4-yl) acetamido] -3-(4-methyl-1-piperazinyl) carbonyloxymethyl-3-cephem -4-carboxylic acid (syn isomer); pharmaceutically acceptable salts thereof; and processes for their preparation. The invention also relates to pharmaceutical compositions comprising, as an effective ingredient, the above compounds in association with a pharmaceutically acceptable, substantially nontoxic carrier or excipient; and to a process for their preparation.