NEUE 4-BENZYL-1- (2H) -PHTHALAZINON-DERIVATE MIT EINEM AMINOSAEUREREST

摘要

Anti-asthmatically acting compounds of formula IMAGE I wherein R1 and R2 represent hydrogen, fluorine, chlorine, bromine, trifluoromethyl, C1-C6-alkyl or C1-C6-alkoxy and the radical A is the group IMAGE wherein R3 is hydrogen, a phenyl radical, an indolyl-(3)-methyl radical, imidazolyl-(4)-methyl radical, a C1-C10-alkyl group or wherein R3 represents a C1-C10-alkyl group which is substituted by a carboxy group, a C1-C6-alkoxycarbonyl group, an aminocarbonyl group, a hydroxy group, a C1-C6-alkoxy group, a C2-C6-alkanoyl-oxy group, a mercapto group, a C1-C6-alkylthio group, a C2-C6-alkanoylmercapto group, a phenyl group, a hydroxyphenyl group, a dihydroxyphenyl group, an amino-C1-C6-alkylthio group, an amino-C1-C6-alkyloxy group, an amino group, a ureido group (H2NCONH-) or a guanidino group or wherein R3 together with the structural moiety CH(NHR4) represents the pyrrolidine-2-yl-radical (proline radical) or the 4-hydroxypyrrolidine-2-yl radical, R4 is hydrogen, benzyl or a C1-C6-alkyl radical, R5 is hydrogen, benzyl, a C1-C6-alkyl radical, a C2-C6-alkanoyl radical or the group. IMAGE where R3 and R4 have the meanings given above and R6 is hydrogen, benzyl or C2-C6-alkanoyl, and physiologically acceptable salts therof, and processes for their preparation.