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AMINO ACID CHELATED COMPOSITIONS FOR DELIVERY TO SPECIFIC BIOLOGICALTISSUE SITES

机译:交付给特定生物问题场所的氨基酸螯合组合物

摘要

ABSTRACT OF THE DISCLOSUREAmino acid chelates having a ligand to divalent metal moleratio of at least 2:1 and having a molecular weight of notmore than 1500 and preferably not more than 1000 and alsohaving a stability constant of between about 106 and1012 are formulated for delivery to one or more specifictissue sites within a mammal. The ligand utilized informulating the amino acid chelate is a naturally occuringamino acid or a dipeptide, tripeptide or quadrapeptidethereof. The selection of an appropriate ligand with whichto form the chelate provides a product that, when enteringthe bloodstream of the mammal, either by mean of oralingestion or injection, has a propensity to migrate to oneor more targeted tissue sites within the mammal.
机译:披露摘要对二价金属分子具有配体的氨基酸螯合物至少2:1的分子量比大于1500,最好不大于1000,并且具有约106到100之间的稳定常数1012被制定为交付给一个或多个特定哺乳动物内的组织部位。用于的配体配制氨基酸螯合物是天然存在的氨基酸或二肽,三肽或四肽其。选择合适的配体形成螯合物提供了一种产品,当进入哺乳动物的血液,通过口服摄入或注射,倾向于迁移到一个或哺乳动物内更多的靶向组织部位。

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