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AMINO ACID CHELATED COMPOSITIONS FOR DELIVERY TO SPECIFIC BIOLOGICAL TISSUE SITES

机译:交付给特定生物组织场所的氨基酸螯合组合物

摘要

Amino acid chelates having a ligand to divalent metal mole ratio of at least 2:1 and having a molecular weight of not more than 1500 and preferably not more than 1000 and also having a stability constant of between about 10 and 10 are formulated for delivery to one or more specific tissue sites within a mammal. The ligand utilized in formulating the amino acid chelate is a naturally occuring amino acid or a dipeptide, tripeptide or quadrapeptide thereof. The selection of an appropriate ligand with which to form the chelate provides a product that, when entering the bloodstream of the mammal, either by mean of oral ingestion or injection, has a propensity to migrate to one or more targeted tissue sites within the mammal.
机译:将配体与二价金属的摩尔比为至少2∶1且分子量不大于1500,优选不大于1000并且还具有约10至10的稳定常数的氨基酸螯合物配制成用于递送至哺乳动物内的一个或多个特定组织部位。用于配制氨基酸螯合物的配体是天然存在的氨基酸或其二肽,三肽或四肽。选择与之形成螯合物的合适配体提供了这样一种产品,当其通过口服摄取或注射进入哺乳动物的血流时,其倾向于迁移到哺乳动物内的一个或多个目标组织部位。

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