HEMATOPOIETIC CELL SPECIFIC TRANSCRIPTIONAL REGULATORY ELEMENTS OF SERGLYCIN AND USES THEREOF

摘要

A negative transcription regulatory element (a constitutive suppressor) between residues -250 and -190 of the 5' flanking region of the mouse serglycin gene, a positive (hematopoietic cell enhancer) regulatory element located between residues -118 and -81, an equivalent of the TATA- box and a novel eukaryotic promoter that utilizes such equivalent, vectors containing such elements and hosts transformed therewith, are described. These regulatory elements, vectors and hosts are useful in gene transcription of heterologous genes in eukaryotic cells, and especially in hematopoietic cells. In addition, transcriptional factors that bind to these elements are described.