Method and compositions for treatment of pyonecrotic processes

摘要

The present invention is directed to compounds useful for hydrolyzing proteins in pyonecrotic matter comprising a protease attached to a hydrophilic gel or to the gel in combination with water-soluble polymer. The compound preferably comprises subtilisins covalently attached to polyethylene glycol (PEG): gel combined with PEG in liquid form. The invention is further directed to methods of preparing a gel by electron beam radiation, and sterilizing the mixture with radiation, preferably by electron beam or gamma-ray radiation. The present invention also relates to methods of hydrolyzing proteins by administering an effective amount of the proteolytic compounds of the present invention.