Methods and Compositions for Treatment of Central Nervous System Injury with Isothiocyanates.

摘要

Methods and compositions comprising isothiocyanates or derivatives or metabolites thereof, for attenuating or preventing central nervous system tissue damage, and/or improving cognitive function, are disclosed. Treatment of head trauma, spinal cord injury, stroke, aging, neurological diseases, and other insults to the central nervous system that compromise the blood-brain barrier, cause brain swelling, central nervous system cell death, or cognitive or motor dysfunction, by administering an isothiocyanate such as sulforaphane, allyl isothiocyanate, phenylethyl isothiocyanate, or a related compound, is also disclosed.