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Process for making L-phenyl acetyl carbinol (PAC), microorganisms for use in the process, and a method of preparing the microorganisms
Process for making L-phenyl acetyl carbinol (PAC), microorganisms for use in the process, and a method of preparing the microorganisms
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机译:L-苯基乙酰基甲醇(PAC)的制备方法,用于该方法的微生物以及制备该微生物的方法
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摘要
Mutations are induced in a microorganism selected from the species Saccharomyces cerevisiae or from the species Candida flareri. The resulting mutants are cultured in the presence of a fermentation inhibitor, such as acetaldehyde, ephedrine or PAC-dione, to form colonies having resistance to the inhibitor. Cells from the colonies are isolated and tested for yield of phenyl acetyl carbinol (PAC) in a fermentation with benzaldehyde and pyruvate. Yeast cells from the colonies that produce elevated levels of PAC are selected for use in subsequent fermentations. PAC is useful as an intermediate in the preparation of l- ephedrine and d-pseudoephedrine, two well-known medicinal chemicals.
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