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RECOMBINANT RETROVIRUS VECTOR USING BABOON ENDOGENOUS VIRUS AND ITS USE
RECOMBINANT RETROVIRUS VECTOR USING BABOON ENDOGENOUS VIRUS AND ITS USE
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机译:狒狒内源性病毒的重组逆转录病毒载体及其用途
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摘要
PURPOSE: To obtain a new retrovirus vector useful for thoroughly transducing an exogenote into a human cell system and expressing the exogenote therein. ;CONSTITUTION: The recombinant retrovirus vector has (a) a DNA sequence in a reverse transcript of an RNA sequence containing a 5'-LTR region and at least a part of a gag region in a baboon endogenous virus, (b) a DNA sequence of an exogenote and (c) a DNA sequence in a reverse transcript of an RNA sequence containing a 3'-LTR region in the baboon endogenous virus from the 5'-side. This recombinant retrovirus vector is obtained by cleaving (a) the 5'-LTR region and at least the part of the gag region and (c) the 3'-LTR region with a suitable restriction enzyme from the DNA sequence of the reverse transcript of the RNA sequence in the baboon endogenous virus and inserting the exogenote between the DNA sequences (a) and (c).;COPYRIGHT: (C)1994,JPO
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