Use of terfenadine derivatives as antihistamines in patients with hepatic impairment (Use of Terfenadine Derivatives as Antihistamines in a Hepatically Impaired Patient)

摘要

The present invention relates to a method of providing an antihistamine effect to said patient comprising administering to a patient suffering from liver damage an effective amount of an antihistamine of the following formula (I) or a pharmaceutically acceptable salt thereof and an isomer thereof.;In the above formula, R_OneIs hydrogen or hydroxy, R₂Is hydrogen, or R_OneAnd R₂Together with R_OneAnd R₂N is an integer from 1 to 5 and R is-COOH or-COO alkyl wherein the alkyl moiety is a straight or branched chain having from 1 to 6 carbon atoms, and A And B are each hydrogen or hydroxy, provided that at least one of A or B is hydrogen.