THIONO TRIESTER MODIFIED ANTISENSE OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATES

摘要

Antisense oligonucleotides having improved cellular uptake, increased nucleaseresistance, and thermodynamically more stable target-binding capacity aredisclosed. These novel oligonucleotides are characterized by having from 1 to10 thiono-triester phosphorothioate internucleoside linkages bearinglipophilic moieties.