Thiono triester modified antisense oligodeoxynucleotide phosphorothioates

摘要

Antisense oligonucleotides having improved cellular uptake, increased nuclease resistance, and thermodynamically more stable target-binding capacity are disclosed. These novel oligonucleotides are characterized by having from 1 to 10 thiono-triester phosphorothioate internucleoside linkages bearing lipophilic moieties.