HUMAN TUMOROUS NECROTIC FACTOR, PROCESS OF ITS PRODUCTION, DNA ENCODING THE HUMAN TUMOROUS NECROTIC FACTOR, A CELL TRANSFORMED BY THIS DNA, AGENT IN WHICH THE HUMAN TUMOROUS NECROTIC FACTOR IS COMPRISED AND AGENT SUITABLE TO TREATING TUMORS

摘要

Methods and compositions are provided for the purification of a protein identified as tumor necrosis factor from nonrecombinant and recombinant sources, the preparation of nucleic acid encoding this tumor necrosis factor and for its expression in recombinant hosts. This tumor necrosis factor is used in the therapeutic treatment of malignant tumors, either alone or in synergistic combination with an interferon.