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HUMAN ENDOTHELIAL VASCULAR ADHESION PROTEIN-1 (VAP-1), ANTIBODIES, METHODS OF DIAGNOSIS AND PHARMACEUTICAL COMPOSITIONS
HUMAN ENDOTHELIAL VASCULAR ADHESION PROTEIN-1 (VAP-1), ANTIBODIES, METHODS OF DIAGNOSIS AND PHARMACEUTICAL COMPOSITIONS
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机译:人血管内皮粘附蛋白1(VAP-1),抗体,诊断方法和药物成分
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摘要
A novel endothelial cell molecule, VAP-1, that mediates lymphocyte binding in man, is described. Anti-VAP-1 monoclonal antibodies are described and the monoclonal antibody 1B2 is provided by this invention, as well as the hybridoma cell line (DSM ACC2041) which produces it. This invention further provides methods for the treatment of inflammatory and autoimmune diseases by the administration of VAP-1 binding compounds, such as anti-VAP-1 antibodies.
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