TARGETED HETERO-ASSOCIATION OF RECOMBINANT PROTEINTARGETED HETERO-ASSOCIATION OF RECOMBINANT PROTEINS TO MULTI-FUNCTIONAL COMPLEXES S TO MULTI-FUNCTIONAL COMPLEXES

摘要

The present invention relates to a method for targeted assembly of distinct active peptide or protein domains into a single complex and to such complexes. The invention relates particularly to the fusion of peptide or protein domains to complementary association domains which are derived from a single tertiary or quaternary structure by segmentation. The association domains are designed to assemble in a complementary fashion, thereby providing multifunctional (poly)peptides.