DNA molecules and novel proteins related to gene expression repression

摘要

P21 is a region lacking in the provirus and contains a DNA molecule which has a gene expression inhibitory function from human T-cell leukemia virus type I (HTLV-I) in the region of the complete provirus and contains the DNA molecule Provide a plasmid. In addition, a novel protein (TRP-1) that specifically binds to u5re, which can be useful for elucidating the transcriptional repression activity involved in the transcriptional repressor region (u5re) in the U5 region of the human T-cell leukemia virus type I gene and the oncogenic mechanism of nerve cells, and its Tampa Provide a structural gene of the protein. In addition, an expression vector having the gene, a transformant incorporating the expression vector, and a method of producing TRP-1 protein using the transformation body are provided.