A process for the preparation of lercanidipine hydrochloride hydrochloride and metiloanhidro 1.1, N - (N - trimethyl - 3.3 - n) - 2 - aminoethyl - 1,4 - dihydro - 26 - dimethyl - 4 - (3-nitrophenyl) - piridino - 3.5 - dicarboxilato obtained by this procedure.

摘要

The preparation procedure of 1,1,1,1,1,n-trimethyl-n (3,3,3-diphenylpropyl) - 2,4-dihydro-2,6-dimethyl-4 - (3-nitrophenyl) - pyridine-3,5-dicarbonate (lercanidino) includes the reaction of halide 2,6-dimethyl-5-methoxy-4 - (3-nitrophenyl).-1,4-dihydropyridine-3-an original solvent containing 2, N-dimethyl-N - (3, 3-diphenyl) - 1-amino-2-propanol. The product can be separated by the intermediate crystallization technology which can be applied in industry and produced by the high performance of its hydrochloride.A form with high stability and low humidity