Compound pharmaceutical composition and process to inhibit protein farnesyltransferase to treat cancer benign proliferative neurofibromine blindness infections of hepatitis delta and viruses related to polycystic kidney disease to prevent restenosis and to treat or prevent a disease

摘要

The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.