Process for the preparation of compound Intermediate N - acetyl - (L) - 4 - (L) - cianofenilalanina AC PHE (CN) - Oh is particularly useful in the preparation of N - acetyl - (L) - P - amidinofenilalanina - ciclohexIlglicina beta - (3) - N - metilpiridinio) alanine and Procedure for the preparation of compound N - acetyl - (L) - P - ciclohexilglicina amidinofenilalanina - beta - (3) - N - metilpiridinio) alanine

摘要

The present Invention relates to a process for the preparation of N - acetyl - (L) - 4 - cianofenilalanina from Racemic Ester Compound etilicode N - acetyl - (D,L) - cianofenilalanina understand the stages of combining this compuestoracemi co, a sufficient amount of an aqueous solution, sufficient amount of acetonitrileA sufficient amount of subtilisin to react with a substantial amount of Racemic Compound formarun reaction medium to adjust the Med's reaction when an appropriate pHAde subtilisin and maintenance of proper pH while unareaccion takes place to produce the desired Compound.Also described is a method for obtaining N - acetyl - (L) - amido phenylalanine ciclohexilglicina beta - (3) - N - metilpiridinio) alanine, which comprises the steps of the intermediary - copulate ACETIl - (L) - 4 - cianofenilalanina with amide (L) - ciclohexilglicina - (L) - beta - (3-pyridyl) - alanine yconversion, cyano Group of this Compound copulated,In the Group amidino and methylation delpiridilo nitrogen to give the desired Compound is particularly useful in the inhibition of factor Xa in the clotting of Blood.