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Live recombinant vaccine based on canine herpesvirus, especially against rabies, rabies or type 2 parainfluenza virus
Live recombinant vaccine based on canine herpesvirus, especially against rabies, rabies or type 2 parainfluenza virus
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机译:基于犬疱疹病毒的活重组疫苗,特别是针对狂犬病,狂犬病或2型副流感病毒的重组疫苗
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摘要
Disclosed and claimed is a recombinant canine herepes virus (CHV). The recombinant CHV includes and expresses at least one heterologous nucleotide sequence encoding an antigen. The antigen can be canine distemper virus HA, canine distemper virus F, rabies virus G, canine parvovirus VP2, parainfluenza virus type 2 HA, parainfluenza virus type 2 F, Borrelia burgdorferi OspA, or Borrelia burgdorferi OspB. The at least one heterologous nucleotide sequence can be in at least one insertion site selected from the group consisting of ORF3 (SEQ ID NO:4), ORF5 (SEQ ID NO:5), the thymidine kinase gene, and the intergenic region corresponding to genes coding for the large subunit and the small subunit. Immunological or vaccine compositions as well as methods for inducing an immunological response are also disclosed and claimed.
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机译:公开并要求保护的是重组犬异位病毒(CHV)。重组CHV包括并表达至少一种编码抗原的异源核苷酸序列。抗原可以是犬瘟热病毒HA,犬瘟热病毒F,狂犬病病毒G,犬细小病毒VP2,副流感病毒2型HA,副流感病毒2F型,伯氏疏螺旋体OspA或伯氏疏螺旋体OspB。所述至少一个异源核苷酸序列可以在选自由以下各项组成的组的至少一个插入位点中:ORF3(SEQ ID NO:4),ORF5(SEQ ID NO:5),胸苷激酶基因和与编码大亚基和小亚基的基因。还公开并要求保护了免疫学或疫苗组合物以及诱导免疫学应答的方法。
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