A method for inhibiting metastasis and tumor cell growth by clinically modulating tumor expression of fas ligand

摘要

A method for impairing metastasis and tumor growth in an individual having solid nonlymphoid tumor that comprises FasL(-) tumor cells. The method comprises administering to the individual a therapeutical1y effective amount of a pharmaceutical composition that contacts and causes FasL expression by the tumor cells. Also disclosed is a method for treating FasL(-) tumor cells to become FasL comprising contacting the FasL(-) tumor cells with a therapeutically effective amount of a pharmaceutical composition that acts to cause FasL expression. The FasL+ tumor cells, in nonadherent conditions, may impair metastasis and tumor growth by contacting and inducing Fas mediated cytotoxicity of Fas expressing tumor cells, and/or Fas expressing B cells involved in a pro-tumor immune response. The composition for causing FasL expression in FasL(-) tumor cells comprises a biological modifier or an expression vector encoding FasL.