首页> 外国专利> methods to inhibit b cell tumor cell proliferation, to treat a patient having a tumor, to treat a patient having a deregulated taki signaling transduction molecule, to inhibit the growth of a solid tumor, to select a patient having a tumor THAT IS SUSTAINABLE to treatment with a taki inhibitor, to inhibit the proliferation of a cell leukemia and t-cell lymphomas, and to select a mammal having or methods to inhibit the proliferation of b cell tumor cell, to treat a patient having a tumor, to treat a patient having a deregulated tak1 signaling transduction molecule, to inhibit the growth of a solid tumor, to select a patient having a tumor that is susceptible to treatment with a tak1 inhibitor, to inhibit the proliferation of a cell leukemia and t-cell lymphomas, and to select a mammal having or suspected of having a tumor for treatment with a medi inhibitor tak1

methods to inhibit b cell tumor cell proliferation, to treat a patient having a tumor, to treat a patient having a deregulated taki signaling transduction molecule, to inhibit the growth of a solid tumor, to select a patient having a tumor THAT IS SUSTAINABLE to treatment with a taki inhibitor, to inhibit the proliferation of a cell leukemia and t-cell lymphomas, and to select a mammal having or methods to inhibit the proliferation of b cell tumor cell, to treat a patient having a tumor, to treat a patient having a deregulated tak1 signaling transduction molecule, to inhibit the growth of a solid tumor, to select a patient having a tumor that is susceptible to treatment with a tak1 inhibitor, to inhibit the proliferation of a cell leukemia and t-cell lymphomas, and to select a mammal having or suspected of having a tumor for treatment with a medi inhibitor tak1

机译:抑制b细胞肿瘤细胞增殖,治疗患有肿瘤的患者,治疗患有taki信号转导分子失调的患者,抑制实体瘤生长,选择具有治疗可持续性的肿瘤的方法使用taki抑制剂来抑制细胞白血病和t细胞淋巴瘤的增殖,并选择具有抑制b细胞肿瘤细胞增殖的哺乳动物或方法,以治疗患有肿瘤的患者,以治疗患有t细胞淋巴瘤的患者失调的tak1信号转导分子,以抑制实体瘤的生长,选择患有对tak1抑制剂治疗敏感的肿瘤的患者,以抑制细胞白血病和t细胞淋巴瘤的增殖,并选择患有或怀疑患有肿瘤的哺乳动物可使用tak1抑制剂治疗

摘要

METHODS TO INHIBIT B-CELL TUMOR CELL PROLIFERATION, TO TREAT A PATIENT HAVING A TUMOR, TO TREAT A PATIENT HAVING A DETRANSDUCTED SIGNALING MOLECULE, TO DISHES, TO UNHEDGE A TUMOR, TO INHIBE A SMOOTHING, TO UNHEDGE A TUMOR. WHICH IS SUBJECT TO TREATMENT WITH A TAK1 INHIBITOR, TO INHIBIT THE PROLIFERATION OF A T-CELL LEUKEMIA AND T-CELL LYMPHOMAS, AND TO SELECT A MAMMALIAN HAVING OR SUSPECTED TO HAVE A TUMOR FOR TREATMENT OF A TUMOR INHIBITOR TAKI. The invention includes, in part, a method of inhibiting lymphoid tumor cell proliferation by contacting the lymphoid with a TAKI inhibitor.
机译:抑制B细胞肿瘤细胞增生,治疗具有肿瘤的患者,治疗具有未分化信号分子的患者,用于盘旋,消除肿瘤,抑制平滑,消除肿瘤的方法。可以使用TAK1抑制剂进行治疗,抑制T细胞白血病和T细胞淋巴瘤的增生,并选择拥有或怀疑拥有肿瘤以治疗肿瘤抑制剂Taki的哺乳动物。本发明部分地包括通过使淋巴样物质与TAKI抑制剂接触来抑制淋巴样瘤细胞增殖的方法。

著录项

  • 公开/公告号BRPI0714158A2

    专利类型

  • 公开/公告日2012-12-25

    原文格式PDF

  • 申请/专利权人 ASTRAZENECA AB;

    申请/专利号BR2007PI14158

  • 申请日2007-07-10

  • 分类号C12Q1/68;

  • 国家 BR

  • 入库时间 2022-08-21 16:42:19

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