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USE OF MURINE MYOSIN HEAVY CHAIN PROMOTERS FOR GENE THERAPY AND PRODUCTION OF TRANSGENICS
USE OF MURINE MYOSIN HEAVY CHAIN PROMOTERS FOR GENE THERAPY AND PRODUCTION OF TRANSGENICS
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机译:小鼠肌球蛋白重链启动子在基因治疗和转基因生产中的应用
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摘要
A murine α and β murine myosin heavy chain (MyHC) promoter is used in gene transfer, gene therapy, and production of transgenics. In larger animals the promoter is expressed in only striated muscle. Therefore, the promoter can be used for efficient, high levels of expression of a gene of interest specifically in striated muscle tissue. This makes it perfect for use in gene therapy of muscle-related diseases such as Duschenne Muscular Dystrophy (DMD) and even systemic diseases, particularly inflammatory diseases.
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