process for the production of (-) - n - methyl - n - 4 - (4 - phenyl - 2 - acetylaminopiperidin - 1-yl) - 2 - (3,4 - dichlorophenyl) butyl - benzamid and its pharmaceutical acceptable salt

摘要

A process is described for the preparation of (+)-2-(3,4-dichlorophenyl)-4-hydroxybutylamine of formula (I) and for the preparation of the (-)-N-methyl-N-Ä4-(4-phenyl-4-acetylamino-piperidin-1-yl)-2-(3,4-dichl orophenyl)butylÜ benzamide and of its pharmaceutically acceptable salts using the compound of formula (I) as synthesis intermediate.