Gene construction, use of a gene construct, paired two-component system, designed for use in a mammalian host, and process for transferring a cytotoxic drug to a site

摘要

'' GENE CONSTRUCTION, USE OF A GENE CONSTRUCTION, SYSTEM OF TWO PAIRED COMPONENTS, DESIGNATED FOR USE IN A MAMMALIAN HOST, AND, PROCESS FOR TRANSFERING A CYTOXOTIC MEDICINE TO A SITE ". The invention provides a gene construction that encodes a target cell portion and a heterologous pro-drug activating enzyme for use as a drug in a mammalian host where the gene construct is capable of expressing the target cell portion and the enzyme as a conjugate within a cell target in the mammalian host and where the conjugate is directed to leave the cell thereafter for selective localization in a cell surface antigen recognized by the target portion of the cell.