HBV SURFACE ANTIGEN PARTICLES, PREPARED BY RECOMBINANT DNA PROCESSES, COMPOSED OF DIFFERENT EPITOPES, SELECTED FROM THE PRE-S AND S-PEPTIDES AS A NEW VACCINE

摘要

HBV surface antigen particles, prepared by recombinant DNAtechnology are described, said particles being composed ofepitopes from the group of surface peptides and/or core peptideof non-A, non-B hepatitis virus, hepatitis virus A and/orhepatitis virus B. Respective particles are especiallycharacterized by a composition of different epitopes selectedfrom pre-S and S peptides. There are also describedDNA-sequences, plasmids and cell lines coding for respective HBVsurface antigen particles as well as a new vaccine containing thesame.