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Binding partner and method for the competitive inhibition of binding between nefprotein and calmodulin, agent containing said binding partner and it use in hiv -related diseases

机译:结合配偶体和竞争性抑制神经蛋白与钙调蛋白结合的方法,含有该结合配偶体的试剂及其在艾滋病相关疾病中的应用

摘要

The invention relates to binding partners for NEF protein or calmodulin which competitively inhibit the binding between calmodulin and NEF protein, as well as to a method for the intra- and/or extracellular competitive inhibition of binding between NEF protein and calmodulin. According to the method, at least one of the two binding partners is brought into contact with HIV-infected cells. The invention further relates to pharmaceutical preparations containing at least one of these binding partners and to the use of the binding partners in the prevention, diagnosis and/or treatment of HIV-related diseases.
机译:本发明涉及竞争性抑制钙调蛋白与NEF蛋白之间结合的NEF蛋白或钙调蛋白的结合伴侣,以及涉及NEF蛋白与钙调蛋白之间的细胞内和/或细胞外竞争性抑制的方法。根据该方法,使两个结合伴侣中的至少一个与HIV感染的细胞接触。本发明进一步涉及包含这些结合伴侣中的至少一种的药物制剂,以及该结合伴侣在预防,诊断和/或治疗HIV相关疾病中的用途。

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