SULFONAMIDES, PHARMACEUTICAL COMPOSITION BASED ON SAID, METHOD OF TREATMENT OF ENDOTHELIN-DEPENDENT DISEASES, METHOD OF INHIBITION OF BINDING ENDOTHELIN PEPTIDE WITH ENDOTHELIN_A-(ET_A) OR _B-(ET_B) RECEPTOR, METHOD OF MODULATION OF ACTIVITY INDUCING BY ENDOTHELIN RECEPTOR

摘要

FIELD: organic chemistry. SUBSTANCE: invention describes the novel sulfonamides of the general formula (I) where values Ar², R¹, R² are given in p. 1 of the invention claim that can be used for inhibition of binding endothelin peptide with endothelin receptors in contact of receptors with sulfonamide. Invention describes also methods of treatment of endothelin-dependent diseases, method of inhibition of binding endothelin peptide with endothelin_A-(ET_A) or _B-(ET_B) receptors and method of modulation of activity inducing by endothelin receptors and pharmaceutical composition based on compounds of the formula (I). EFFECT: new sulfonamides indicated above, improved method of treatment and inhibition. 127 cl, 13 tbl, 445 ex