Pharmaceutical composition for use in the treatment of a condition that requires regular Metabolism of nicotine to cotinine, Search Method, a substance that composes IT,Method for identifying individuals who need Treatment With This composition and uses.

摘要

CYP2A6 is the main Enzyme metabolizing nicotine in livers of human beings.It can be used for Selective inhibitors of CYP2A6 yespecu00edficos to regulate the Metabolism of nicotine and, in particular, substantially reduce the Metabolism of nicotineAffecting the use of Tobacco.Describes a Pharmaceutical composition for use in the treatment of a condition that requires regular Metabolism of nicotine in cotininaque comprises an effective amount of a substanceIt selectively Inhibits the CYP2A6 and a Carrier, diluent or Carrier acceptable to usofarmacu00e9utico.This substance comprises at least a compound that has a structure with a carbonyl lactone portion.Also look for a substance aredescribed amethod that selectively inhibit CYP2A6 to be used in such a Composition and a method for identifying Individuals with the necesitantratamientoComposition.This substance is used in the preparation of pharmaceutical unacomposicion regulates the Metabolism of nicotine encotinina in an individual and is used in prophylaxis or treatment of cancer.