Mutant enzyme producing nucleoside-5'-phosphate, methods for the production of a mutant enzyme producing nucleoside-5' -phosphate, an inhibitor for an enzyme phosphatase or transfosphoylation and a nucleoside-5'-phosphate, crystals of an enzyme, acid phosphatase and acid phosphatase complex, gene, recombinant DNA, and, micro-organism

摘要

ENZIA MANMANMANNUCLEOS4-5'-Phospspsphate PRODUCIN AN ENZIMUTANTANTANNUCLEAN NUCLEOS DEO-5'-PHOSFPRODUCER FROM AN INIBIOR TO AN ENZIPHOSFATASEOR OR TRANS-PhoPhoPhoPhoPhoPhoPhosphine and NUCLE-5'-FO-PhospATATATAT, CRISTAOF A ZI, AN ATAT AT AT AT AT AT, ATATATATATATATATATATDNA, ASEAT AT AT AT AND OF PASPASPASPASPASPAS, AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT AT-5-5-5-5-5-5-5-FICLECLECLEOS-5'--FIFINTE, E, MICROORGANISM." A mutant enzyme producing nucleoside-5'-phosphate having a high productivity of nucleoside-5'-phosphate of an enzyme having a transphosphatase activity and/or phosphatase activity. By identifying the variations based on structural analysis of known enzymatic crystal X-rays,It was found that the enzyme above has a structure in which, in the enzyme producing nucleoside-5'-phosphate, a Lys residue, two Arg residues and two His residues are present, the C 244 gt distances; among these residues are within a specific range, and there is a space allowing nucleoside binding around these residues. wastes.