Hybrid nucleic acid molecule, expression vector, processes for preparation and for the production of recombinant lipid psa protein, recombinantly produced isolated and purified lipid protein, immunological composition, processes to induce an immune response in an animal and to immunize a host against pneumococcal infection, and, immunogenic composition for intranasal administration to a host

摘要

"HYBRID NUCLEIC ACID MOLECULE, EXPRESSION VECTOR, PROCESSES FOR PREPARATION AND PRODUCTION OF POMA RECOMBINANT LIPID PROTEIN PROTECT POMA ISOLATED AND PURIFIED IMMUNIZED HUMIDITY, HUMOROUS, HUMIDIFIED, HUMIDIFIED, HUMIDIFIED AGAINST PNEUMOCOCCIC INFECTION, AND, IMMUNOGENEOUS COMPOSITION FOR INTRANASAL ADMINISTRATION TO A HOSTEL "The present invention relates to recombinant lipidized PsaA proteins and recombinant constructs from which these lipidized PsaA proteins can be expressed. The invention also relates to lipidized PsaA proteins in which lipidation is carried out using a heterologous leader sequence derived from the Borrelia burgdorferi ospA gene, whose leader sequence is conjugated in a translation reading matrix with the psaA structural gene. The invention also provides processes for preparing lipidized PsaA proteins and the use of these proteins in immunological compositions. Vaccines are also provided comprising immunogenic lipidized PsaA proteins and processes for using these vaccines to prevent and treat infection with S. pneumoniae.