Altered g protein or rsv polypeptide, use of it, nucleic acid molecule encoding an altered g protein or rsv polypeptide, nucleic acid construction, recombinant host cell, processes of producing an altered g protein or rsv polypeptide immunogenic composition , to induce an immune response in a vertebrate, to inhibit the induction of disease increase after vaccination and subsequent infection of a vertebrate with rsv and to immunize a vertebrate against rsv, vaccine composition, vaccine, and, composition immunogenic

摘要

"ALTERED G PROTEIN OR POLYPEPTIDE OF THE RSV, USE OF THE SAME, NUCLEIC ACID MOLECULE ENCODING AN ALTERED G PROTEIN OR AN RSV POLYPEPTIDE, BUILDING NUCLEIC ACID, RECOMMENDED HOSEPHERE CELL, PROCESSED BY A PROTEIN OF HYDROPULATIC PROTEIN. IMMUNOGENIC, INDUCING AN IMMUNE RESPONSE IN A VERTEBRATE, INHIBITING THE INDUCTION OF INCREASED DISEASE AFTER VACCINATION AND THE SUBSEQUENT INFECTION OF A VERTEBRATE WITH RSV AND IMMUNIZATION OF A VERTEBRATE AGAINST VACCINATION, VARIATION, COMPOSITION, VARIATION, COMPOSITION IMMUNOGENIC COMPOSITION ". an altered G protein or part of it from RSV is presented which retains immunogenicity and which, when incorporated into an immunogenic composition or vaccine and administered to a vertebrate, does not induce an increase in the disease (for example, atypical pulmonary inflammation such as pulmonary eosinophilia) after subsequent infection with RSV. In a particular embodiment, the altered G protein comprises a change in the region from amino acid 184 to amino acid 198. Immunogenic compositions and vaccines comprising the altered G RSV protein, and optionally comprising the F RSV protein, are also shown.