Sulfuric acid esters of sugar alcohols to inhibit migration and proliferation of smooth vessel wall muscle cells

摘要

Sulphate ester derivs. (I) of sugar alcohols and related cpds., of formula E1-D-E2 (Ia) and E1-W(E2)-E3 (Ib), and their salts, are new. E1 = (X6-Y3)n3-(X5-Z1)m3-(X4-Y2)n2-(X3-Q1/ SB)m2-(X2-Y1)n1-(X1-A1)m1; E2 = (X12-Y6)n6-(X11-Z2)m6-(X10-Y5)n5-(X9-Q 2)m5-(X8-Y4)n4-(X7-A2)m4; and E3 = (X18-Y9)n9-(X17-Z3)m9-(X16-Y8)n8-(X15-QSB 3)m8-(X14-Y7)n7-(X13-A3)m7. n1-n9 = 0 or 1; m1-m9 = 0 or 1, provided that at least one of m1-m3, at least one of m4-m6 and at least one of m7-m9 = 1; X1-X18 = O, CONR1, NR1CO or NR1; R1 = H or lower alkyl; W = benzene or s-triazine ring; Y1-Y9 = aromatic ring; A1-A3 = residue of sugar alcohol (or deriv.) with one OH gp. removed, residue of a sugar acid (or deriv.), with the 1-COOH gp. removed, or C(CH2OH)3; D = residue of a sugar alcohol (or deriv.) with 2 OH gps. removed, or residue of a sugar diacid (or deriv.) with 2 COOH gps. removed; Q1-Q3, Z1-Z3 = as for D, or a didesoxyglycopyranoside (or deriv.); provided that at least one OH gp. in A1-A3, D, Q1-Q3 and Z1-Z3 is esterified with sulphuric acid.