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Human and mammalian DNA replication origin consensus sequences
Human and mammalian DNA replication origin consensus sequences
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机译:人和哺乳动物DNA复制起点共有序列
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摘要
The present invention relates to a human or mammalian DNA replication origin consensus sequence which consists of a sequence selected from the group consisting of CCTMDAWKSGBYTSMAAWYWBCMYTTRSCAAATTCC (SEQ ID NO: 1); and AWMTWAAKRAWRWWKKDAVWWGAKRWWKWVWHRASSACMDWKAAKTWKGGWTWARRYWKGRKMWWTWKAWSDATAKWWWKDAKWKMWRKTT (SEQ ID NO: 4). A method for the control of initiation of mammalian DNA replication which comprises the steps of: a) inserting a consensus sequence coding for a sequence of the present invention together with a DNA fragment to form a vector capable of expression of the DNA fragment; b) introducing the vector of step a) into mammalian cells in vitro.
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机译:本发明涉及人或哺乳动物DNA复制起点共有序列,其由选自CCTMDAWKSGBYTSMAAWYWBCMYTTRSCAAATTCC的序列组成(SEQ ID NO:1);和AWMTWAAKRAWRWWKKDAVWWGAKRWWKWVWHRASSACMDWKAAKTWKGGWTWARRYWKGRKMWWTWKAWSDATAKWWWKDAKWKMWRKTTTT(SEQ ID NO:4)。一种控制哺乳动物DNA复制起始的方法,该方法包括以下步骤:a)将编码本发明序列的共有序列与DNA片段一起插入,以形成能够表达该DNA片段的载体。 b)将步骤a)的载体体外导入哺乳动物细胞。
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