DNA CONTAINING PROMOTER OF PERIOD 1 GENE, NON-HUMAN ANIMAL INTO WHICH THE DNA IS TRANSDUCED, SYSTEM FOR OBSERVING EXPRESSION AMOUNT OF GENE, AND METHOD FOR OBSERVING EXPRESSION AMOUNT OF GENE

摘要

PROBLEM TO BE SOLVED: To provide a DNA which contains a promoter of period 1 gene and can be used for elucidating the mechanism of the expression regulation of period 1 gene, and a system and a method for observing an in vivo expression amount of a target gene.;SOLUTION: This DNA has two first exons of period 1 gene that are selectively transcripted and two promoter regions having a function as a promoter of the period 1 gene. A non-human animal having the DNA has a DNA construct that is integrated upstream of a reporter gene. The system/method for observation comprises the steps of inserting an optical fiber into an observation region of the non-human animal, obtaining a luminescence generated there, and quantifying it by using a photon counter.;COPYRIGHT: (C)2002,JPO